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FIGURE 1 Tetrahydroprotoberberines Tetrahydroprotoberberines (THPBs) are a series of alkaloids isolated from the traditional Chinese analgesic drug Yanhuasol that act on the dopaminergic system of the CNS and have a far-reaching effect (Jin and Sun, 1995)

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However, despite the efficacy of MT in improving NPDs being confirmed in numerous clinical trials, the molecular mechanisms are not yet fully elucidated, and there is a lack of evidence regarding pathways or targets